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Chemical Structure : Tipifarnib
CAS No.: 192185-72-1
Catalog No.: PC-42624Not For Human Use, Lab Use Only.
Tipifarnib ((IND 58359, R115777) is a potent and selective inhibitor of FTase (farnesyltransferase) with IC50 of 0.86 nM.
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|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Tipifarnib ((IND 58359, R115777) is a potent and selective inhibitor of FTase (farnesyltransferase) with IC50 of 0.86 nM.
Tipifarnib inhibits the farnesylation of lamin B and K-RasB peptide substrates with IC50s of 0.86 nM and 7.9 nM, respectively.
Tipifarnib shows no activity for PGGT1(IC50>50 uM).
Tipifarnib shows sensiticity for tumor cell lines bearing H-ras or N-ras mutations.
Tipifarnib inhibits the growth of tumors bearing mice and orally bioavailable.
| M.Wt | 489.3958 | |
| Formula | C27H22Cl2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2(1H)-Quinolinone, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl- |
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1. End DW, et al. Cancer Res. 2001 Jan 1;61(1):131-7.
2. Kelland LR, et al. Clin Cancer Res. 2001 Nov;7(11):3544-50.
3. Beaupre DM, et al. Mol Cancer Ther. 2004 Feb;3(2):179-86.
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