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Chemical Structure : Tivantinib
CAS No.: 905854-02-6
Catalog No.: PC-45842Not For Human Use, Lab Use Only.
Tivantinib (ARQ-197) is a potent, selective, non-ATP-competitive inhibitor of c-Met with Ki of 355 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $368 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Tivantinib (ARQ-197) is a potent, selective, non-ATP-competitive inhibitor of c-Met with Ki of 355 nM.
Tivantinib (ARQ-197) has no inhibition for EGFR, InsR, PDGFRα, FGFR1 and FGFR4 etc., only modest inhibition (35%) for Ron at 30 uM.
Tivantinib (ARQ-197) inhibits constitutive c-Met phosphorylation in HT29 and MKN-45 cells, and HGF-induced c-Met phosphorylation in MDA-MB-231 and NCI-H441 cells with IC50 of 100-300 nM.
Tivantinib (ARQ-197) shows antiproliferative activity against multiple cancer cell lines (IC50=0.03-30 uM).
Tivantinib (ARQ-197) exerts tumor growth inhibition in multiple mouse xenograft; orally active.
| M.Wt | 369.4159 | |
| Formula | C23H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)- |
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1. Munshi N, et al. Mol Cancer Ther. 2010 Jun;9(6):1544-53.
2. Eathiraj S, et al. J Biol Chem. 2011 Jun 10;286(23):20666-76.
3. Previdi S, et al. Mol Cancer Ther. 2012 Jan;11(1):214-23.
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