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Chemical Structure : Tivozanib
CAS No.: 475108-18-0
Catalog No.: PC-42759Not For Human Use, Lab Use Only.
Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $158 | In stock | |
| 100 mg | $258 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
Tivozanib (AV951) also inhibits EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie2 (IC50=20-80 nM).
Tivozanib (AV951) inhibits VEGF-induced VEGFR-2 phosphorylation in endothelial cells (IC50=0.16 nM).
Tivozanib (AV951) is p.o. active.
| M.Wt | 454.8631 | |
| Formula | C22H19ClN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)- |
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1. Nakamura K, et al. Cancer Res. 2006 Sep 15;66(18):9134-42.
2. Eskens FA, et al. Clin Cancer Res. 2011 Nov 15;17(22):7156-63.
3. Momeny M, et al. Sci Rep. 2017 Apr 6;7:45954.
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