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Chemical Structure : Tofogliflozin
CAS No.: 903565-83-3
Catalog No.: PC-44120Not For Human Use, Lab Use Only.
Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 25 mg | $228 | In stock | |
| 100 mg | $468 | In stock | |
| 500 mg | Get quote |
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Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively; displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1; increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion; reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.
Diabetes
Approved
| M.Wt | ||
| Formula | C22H26O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol, 6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-, (1S,3'R,4'S,5'S,6'R)- |
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1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.
2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40.
3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.
4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.
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