Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Tolcapone
CAS No.: 134308-13-7
Catalog No.: PC-45228Not For Human Use, Lab Use Only.
Tolcapone (Ro 40-7592) selective, potent and reversible nitrocatechol-type inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 700 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Tolcapone (Ro 40-7592) selective, potent and reversible nitrocatechol-type inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 700 nM.
Tolcapone (Ro 40-7592) kills neuroblastoma (NB) cells in preclinical models by inhibition of COMT.
Tolcapone (Ro 40-7592) induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma.
Tolcapone (Ro 40-7592) also is a potent Transthyretin (TTR) aggregation inhibitor.
| M.Wt | 273.2408 | |
| Formula | C14H11NO5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)- |
|
1. Maj J, et al. J Neural Transm Park Dis Dement Sect. 1990;2(2):101-12.
2. Maser T, et al. Cancer Med. 2017 Jun;6(6):1341-1352.
3. Sant'Anna R, et al. Nat Commun. 2016 Feb 23;7:10787.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
