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Chemical Structure : TopBP1 inhibitor 5D4
Catalog No.: PC-21291Not For Human Use, Lab Use Only.
TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.
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TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.
TopBP1 inhibitor 5D4 also inhibits Rad51 foci formation and synergize with inhibitors of PARP1/2 or PARP14.
TopBP1 (topoisomerase IIβ-binding protein 1) functions at the convergent point of Rb, PI3K/Akt, and p53 pathways, making it a promising cancer therapeutic target.
| M.Wt | 466.63 | |
| Formula | C30H34N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fang-Tsyr Lin, et al. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2307793120.
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