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Torcetrapib

Chemical Structure : Torcetrapib

CAS No.: 262352-17-0

Torcetrapib (CP-529414)

Catalog No.: PC-42892Not For Human Use, Lab Use Only.

Torcetrapib (CP-529414) is a potent cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 37 nM.

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Biological Activity

Torcetrapib (CP-529414) is a potent cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 37 nM.
Torcetrapib (CP-529414) shows the potential to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease.

Physicochemical Properties

M.Wt 600.4733
Formula C26H25F9N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-

References

1. Maeda K, et al. Bioorg Med Chem Lett. 2004 May 17;14(10):2589-91.

2. Brousseau ME, et al. N Engl J Med. 2004 Apr 8;350(15):1505-15.

3. Clark RW, et al. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7.

4. Lloyd DB, et al. J Biol Chem. 2005 Apr 15;280(15):14918-22.

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