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Chemical Structure : Torin1
CAS No.: 1222998-36-8
Catalog No.: PC-43314Not For Human Use, Lab Use Only.
Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM).
Torin1 exhibits 100-fold binding selectivity relative to 450 other protein kinases.
Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2, disrupts mTORC1-dependent phenotypes more completely than rapamycin.
Torin1 prevents the anti-inflammatory potency of GC both in human monocytes and myeloid dendritic cells.
| M.Wt | 607.6243 | |
| Formula | C35H28F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.6 mg/mL (Need ultrasonic or warming) |
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| Chemical Name/SMILES |
Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)- |
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1. Thoreen CC, et al. J Biol Chem. 2009 Mar 20;284(12):8023-32.
2. Liu Q, et al. J Med Chem. 2010 Oct 14;53(19):7146-55.
3. Weichhart T, et al. Blood. 2011 Apr 21;117(16):4273-83.
4. Thoreen CC, et al. Autophagy. 2009 Jul;5(5):725-6.
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