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Chemical Structure : Torin2
CAS No.: 1223001-51-1
Catalog No.: PC-43313Not For Human Use, Lab Use Only.
Torin2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25 nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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Torin 2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25 nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases.
Torin 2 also exhibits potent biochemical and cellular activity against PIKK family kinases including ATM (EC50=28 nM), ATR (EC50=35 nM), and DNA-PK (EC50=118 nM).
Torin 2 inhibits mTOR kinase and mTORC1 signaling activities, results in a prolonged block in negative feedback and consequent T308 phosphorylation on Akt in treated cancer cells.
Torin 2 demonstrates significant growth inhibition against KRAS-driven lung tumors combined with MEK inhibitor AZD6244, does not yield significant efficacy as a single agent.
Torin 2 overcomes the resistance of ALK(F1174L)/MYCN tumors to crizotinib in vivo.
| M.Wt | 432.3973 | |
| Formula | C24H15F3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzo[h]-1,6-naphthyridin-2(1H)-one, 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]- |
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1. Liu Q, et al. J Med Chem. 2011 Mar 10;54(5):1473-80.
2. Liu Q, et al. Cancer Res. 2013 Apr 15;73(8):2574-86.
3. Berry T, et al. Cancer Cell. 2012 Jul 10;22(1):117-30.
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