Chemical Structure : Tpl2-IN-34
CAS No.: 915363-56-3
Catalog No.: PC-45794Not For Human Use, Lab Use Only.
A potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
25 mg | $554.4 | In stock | |
100 mg | $740 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM; dispalys 6875-fold selectivity over EGFR. P38, Src, CAMKII, MK2, PKA, and PKC (IC50>10 uM); inhibits LPS-induced TNF-α production in whole blood with IC50 of 0.3 uM; shows good efficacy in inhibiting TNF-alpha production in a LPS-stimulated rat inflammation model; orally active.
M.Wt | 539.4347 | |
Formula | C26H25Cl2FN8 | |
CAS No. | 915363-56-3 | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name |
3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]- |
1. Wu J, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright