Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Tranilast
CAS No.: 53902-12-8
Catalog No.: PC-70135Not For Human Use, Lab Use Only.
Tranilast (MK-341) is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $128 | In stock | |
| 100 mg | $198 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Tranilast (MK-341) is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.
Tranilast (MK-341) is an inhibitor of calcium-permeable TRPV2 channel, inhibits insulin increased calcium entry in beta-cells.
Tranilast inhibits endotoxin-induced PGE2 (IC50=1-20 uM), thromboxane B2 (IC50= 10-50 uM), TGF-β1 (IC50=100-200 uM), and IL-8 (IC50=100 uM) formation, but has no effect on TNF-α.
Tranilast also inhibits VEGF-induced angiogenetic activities.
Tranilast also is an inhibitor of the transcription factor Forkhead box O-1 (FoxO-1).
| M.Wt | 327.33 | |
| Formula | C18H17NO5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]- (9CI) |
|
1. Capper EA, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1061-9.
2. Ikai K, et al. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6.
3. Koyama S, et al. Br J Pharmacol. 1999 May;127(2):537-45.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
