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Chemical Structure : Trequinsin hydrochloride
Catalog No.: PC-62884Not For Human Use, Lab Use Only.
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM.
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Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM; reduces systemic blood pressure in both normotensive and hypertensive animal models.
Hypertension
Discontinued
| M.Wt | 441.956 | |
| Formula | C24H28ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lal B, et al. J Med Chem. 1984 Nov;27(11):1470-80.
2. Ruppert D, et al. Life Sci. 1982 Nov 8;31(19):2037-43.
3. Darius H, et al. Br J Pharmacol. 1985 Mar;84(3):735-41.
4. Blaskó G, et al. Thromb Res. 1986 Jul 15;43(2):249-50.
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