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Chemical Structure : Tucidinostat
CAS No.: 1616493-44-7
Catalog No.: PC-35344Not For Human Use, Lab Use Only.
Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively.
Tucidinostat (HBI-8000) shows no activity against Class IIa HDAC4/4/7/9 and HDAC6.
Tucidinostat (HBI-8000) demonstrates significant and broad spectrum in vitro and in vivo antitumor activity, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
| M.Wt | 390.418 | |
| Formula | C22H19FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide |
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1. Ning ZQ, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9.
2. Gong K, et al. Biochem J. 2012 May 1;443(3):735-46.
3. Dong M, et al. Cancer Chemother Pharmacol. 2012 Jun;69(6):1413-22.
4. Gao S, et al. Anticancer Agents Med Chem. 2017;17(6):802-812.
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