Catalog No.: PC-27510Not For Human Use, Lab Use Only.
Tudociclib (INCB123667) is a potent and selective, orally available small molecule inhibitor of CDK2 with IC50 of <20 nM, is inactive against CDK1, CDK4, CDK6, CDK7, and CDK9.
Tudociclib (INCB123667) is a potent and selective, orally available small molecule inhibitor of CDK2 with IC50 of <20 nM, is inactive against CDK1, CDK4, CDK6, CDK7, and CDK9.
INCB123667 inhibits phosphorylation of retinoblastoma (Rb), a CDK2/cyclin E substrate and key regulator of the G1-S transition.
INCB123667 inhibits the expression of cell cycle regulatory genes in cyclin E-overexpressed cancer cells.
INCB123667 resulted in G1 cell cycle arrest and cell senescence in ceullar assays.
INCB123667 inhibits Rb phosphorylation and resulted in dose-dependent tumor growth inhibition along with minimal body weight loss in OVCAR3 tumor xenograft model.
