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Chemical Structure : Tuvatexib
Catalog No.: PC-35768Not For Human Use, Lab Use Only.
Tuvatexib (Hexokinase 2 modulator Comp-1) is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM.
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Tuvatexib (Hexokinase 2 modulator Comp-1) is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM.
Tuvatexib does not affect the VDAC1/HK1 complex.
Tuvatexib dose-dependent reduces mitochondrial-bound HK2 levels in human skin SCC A431 cells with IC50 of 0.8 uM, reduces glycolysis and triggers apoptosis in cancer cells, without affecting hexokinase 1-expressing normal cells.
Tuvatexib demonstrates anti-cancer activity in UVB-damaged skin model in SKH-1 mice.
| M.Wt | 337.419 | |
| Formula | C21H23NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Behar V, et al. J Invest Dermatol. 2018 Jun 14. pii: S0022-202X(18)32056-6.
2. Goldin N, et al. Oncogene. 2008 Aug 7;27(34):4636-43.
3. Krasnov GS, et al. Expert Opin Ther Targets. 2013 Oct;17(10):1221-33.
4. PCT Int. Appl. (2018), WO 2018083705 A1 20180511.
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