Catalog No.: PC-27551Not For Human Use, Lab Use Only.
UBP310 is a high affinity, selective antagonist of kainate receptor GluR5 with Kd of 130 nM, has >800-fold selecitvity over GluR2 and GluR6, binds to GluK1 with KD of 21 nM, but shows no specific binding to GluK2.
UBP310 is a high affinity, selective antagonist of kainate receptor GluR5 with Kd of 130 nM, has >800-fold selecitvity over GluR2 and GluR6, binds to GluK1 with KD of 21 nM, but shows no specific binding to GluK2. UBP310 also effectively blocks recombinant homomeric GluK3 receptors, but not homomeric GluK2 or heteromeric GluK2/3 receptors. UBP310 is an antagonist of recombinant GluK2/GluK5 receptors, significantly reduces the sustained depolarization and impacts on spike transmission mediated by heterosynaptic signals in hippocampal mossy fiber (MF) CA3 synapses.
