Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : UC-773587
Catalog No.: PC-60885Not For Human Use, Lab Use Only.
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.
UC-773587 dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay.
UC-773587 dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling.
UC-773587 specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts.
UC-773587 inhibits Ras signaling and growth of pancreatic and prostate cancer cells.
| M.Wt | 432.431 | |
| Formula | C28H16O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
