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Chemical Structure : UCB35625
CAS No.: 202796-42-7
Catalog No.: PC-20541Not For Human Use, Lab Use Only.
UCB35625 is a potent, selective inhibitor of CCR1 and CCR3, inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM respectively.
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UCB35625 is a potent, selective inhibitor of CCR1 and CCR3, inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM respectively.
UCB35625 also inhibited the CCR3-mediated entry of the human immunodeficiency virus-1 primary isolate 89.6 into the glial cell line, NP-2 (IC50=57 nM).
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| Formula | ||
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ClC1=CC=C(OC(C=CC(Cl)=C2)=C2C3C(N[C@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C3=C1.[I-] |
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1. Sabroe I, et al. J Biol Chem. 2000 Aug 25;275(34):25985-92.
2. de Mendonça FL, et al. J Biol Chem. 2005 Feb 11;280(6):4808-16.
3. Ansari MA, et al. Immunobiology. 2022 Sep;227(5):152245.
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