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Chemical Structure : UCB7362
Catalog No.: PC-49827Not For Human Use, Lab Use Only.
UCB7362 (UCB 7362) is a potent, selective inhibitor of malaria parasite plasmepsin X (PMX) with IC50 of 7 nM for P. falciparum (Pf PMX) and plasmodium vivax (Pv PMX), SPR Kd of 5.5 nM, also inhibits PMIX with IC50 of 142 nM.
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UCB7362 (UCB 7362) is a potent, selective inhibitor of malaria parasite plasmepsin X (PMX) with IC50 of 7 nM for P. falciparum (Pf PMX) and plasmodium vivax (Pv PMX), SPR Kd of 5.5 nM, also inhibits PMIX with IC50 of 142 nM.
UCB7362 displays high selectivity against Cat D and Renin with an IC50 of 3889 nM and >10,000 nM, respectively.
UCB7362 inhibits parasite growth across all strains tested regardless of geography and resistance profileasexual blood stage (ABS) assay of Pf parasites (3D7 strain, IC50=10 nM).
UCB7362 demonstrated no cross-resistance when tested against drug-resistant Plasmodium strains containing mutations generated with other compounds in development.
UCB7362 is estimated to achieve 9 log 10 unit reduction in asexual blood-stage parasites with once-daily dosing of 50 mg for 7 daysin PfSCID mouse model.
| M.Wt | 479.97 | |
| Formula | C25H26ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martin A Lowe, et al. J Med Chem. 2022 Oct 27;65(20):14121-14143.
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