Chemical Structure : UCT943
Catalog No.: PC-35292Not For Human Use, Lab Use Only.
UCT943 (UCT-943) is a potent, selective, next generation Plasmodium falciparum PI4K inhibitor with IC50 of 23 nM.
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UCT943 (UCT-943) is a potent, selective, next generation Plasmodium falciparum PI4K inhibitor with IC50 of 23 nM; displays higher asexual blood stage, transmission-blocking, and liver stage activity than MMV048 and is more potent against resistant P. falciparum and P. vivax clinical isolates; demonstrates excellent in vitro antiplasmodial activity in P. berghei and humanized P. falciparum mouse models.
M.Wt | 427.431 | |
Formula | C22H20F3N5O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Brunschwig C, et al. Antimicrob Agents Chemother. 2018 Jun 25. pii: AAC.00012-18.
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