UFMylation inhibitor CP-24

Chemical Structure : UFMylation inhibitor CP-24

Catalog No.: PC-27372Not For Human Use, Lab Use Only.

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Biological Activity

UFMylation inhibitor CP-24 is a potent, non-covalent UFMylation inhibitor targeting DDRGK1, disrupts of E3 ligase complex components DDRGK1-UFL1 interaction, binds directly to the DDRGK1 PCI domain, effectively inhibits UFMylation.
CP-24 showed significant upregulation of ER stress-related genes compared to DMSO-treated U87 cells, including HSPA5, XBP1, ERN1, EIF2AK3, CANX, ATF4, and DDIT3.
CP-24 effectively reduces global UFMylation levels, decrease DDRGK1 protein levels, inhibits ER-phagy, and induce ER stress.
CP-24 impairs ER-phagy, induces ER stress, and exhibits robust anti-tumor effects in vitro and in multiple GBM mouse models.

Physicochemical Properties

M.Wt	423.53
Formula	C23H25N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(N,N-diethylsulfamoyl)-4-methylphenyl)-3-(quinolin-2-yl)acrylamide

References

1. Tan P, et al. Signal Transduct Target Ther. 2026 Jul 20;11(1):281.