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Chemical Structure : UK-101
Catalog No.: PC-60966Not For Human Use, Lab Use Only.
A potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.
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A potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey; induces apoptosis of PC-3 cells and results in significant inhibition (~50-60%) of tumour growth in vivo, does not block degradation of IκBα in PC-3 cells treated with TNF-α.
| M.Wt | 484.753 | |
| Formula | C25H48N2O5Si | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.
2. Wehenkel M, et al. Br J Cancer. 2012 Jun 26;107(1):53-62.
3. Lei B, et al. J Phys Chem B. 2010 Sep 30;114(38):12333-9.
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