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UK-500001

Chemical Structure : UK-500001

CAS No.: 582332-31-8

UK-500001 (UK 500001;UK 500,001)

Catalog No.: PC-60726Not For Human Use, Lab Use Only.

A potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively.

Physicochemical Properties

M.Wt 499.49
Formula C26H24F3N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3,4-difluorophenoxy)-5-fluoro-N-((1s,4s)-4-(2-hydroxy-5-methylbenzamido)cyclohexyl)nicotinamide

References

1. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67.

2. Vestbo J, et al. Eur Respir J. 2009 May;33(5):1039-44.

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