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Chemical Structure : UK 356618
Catalog No.: PC-62402Not For Human Use, Lab Use Only.
UK 356618 is a potent and selective MMP3 inhibitor with IC50 of 5.9 nM, shows >140-fold less potent against MMP-1 (IC50=51000 nM), MMP-2 (IC50=1790 nM), MMP-9 (IC50=840 nM) and MMP-14 (IC50=1900 nM).
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UK 356618 (UK356618) is a potent and selective MMP3 inhibitor with IC50 of 5.9 nM, shows >140-fold less potent against MMP-1 (IC50=51000 nM), MMP-2 (IC50=1790 nM), MMP-9 (IC50=840 nM) and MMP-14 (IC50=1900 nM); significantly reduces hemorrhagic transformation and improves functional outcomes in hyperglycemic stroke.
| M.Wt | 557.72 | |
| Formula | C34H43N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fray MJ, et al. Bioorg Med Chem Lett. 2001 Feb 26;11(4):571-4.
2. Hafez S, et al. Stroke. 2016 Mar;47(3):843-51.
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