UOM-005636 | Cyclin K degrader | Probechem Biochemicals

Chemical Structure : UOM-005636

UOM-005636 (UOM005636)

Catalog No.: PC-27703Not For Human Use, Lab Use Only.

UOM-005636 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 85 nM in OCI-AML5 cells, mediates cyclin K degradation through DDB1 bridging the CRL4 complex.

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Biological Activity

UOM-005636 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 85 nM in OCI-AML5 cells, mediates cyclin K degradation through DDB1 bridging the CRL4 complex.

Physicochemical Properties

M.Wt	418.53
Formula	C22H18N4OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(pyridin-2-yl)phenyl)-N-(5-((pyridin-3-ylmethyl)thio)thiazol-2-yl)acetamide

References

1. Moison C, et al. EMBO Rep. 2025 Jun;26(11):2836-2854.

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UOM-005636 (UOM005636)

Biological Activity

Physicochemical Properties

References

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