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Chemical Structure : URML-3881
Catalog No.: PC-72995Not For Human Use, Lab Use Only.
URML-3881 (URML3881) is a potent, specific MEK1/2 inhibitor IC50 of 30 nM in a cell-free kinase inhibition assay.
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URML-3881 (URML3881) is a potent, specific MEK1/2 inhibitor IC50 of 30 nM in a cell-free kinase inhibition assay.
URML-3881 shows no inhibition among a panel of other kinases including MEK 3 and MEK5, which are activated in alternative MAPK signaling pathways.
URML-3881 reduces MAPK pathway activity in clear cell ovarian cancer (CCOC).
URML-3881 causes reduced CCOC viability due to induction of tumor cell apoptosis and inhibition of proliferation.
URML-3881 abrogates cisplatin-induced prosurvival MAPK signaling in CCOC, resulting in durable and dramatic tumor regression in vivo.
| M.Wt | 490.292 | |
| Formula | C16H16FIN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rowswell-Turner RB, et al. Transl Oncol. 2019 Jul;12(7):917-924.
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