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Chemical Structure : UT-11
CAS No.:
Catalog No.: PC-20720Not For Human Use, Lab Use Only.
UT-11 is a potent microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, inhibits PGE2 production from human SK-N-AS and murine BV2 cells induced by LPS with IC50 of 0.1 and 2.0 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
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UT-11 is a potent microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, inhibits PGE2 production from human SK-N-AS and murine BV2 cells induced by LPS with IC50 of 0.1 and 2.0 uM, respectively.
Treatment with UT-11 (10 mg/kg) significantly blunted the upregulation of mPGES-1 induced by LPS in the hippocampus.
UT-11 also blunted thte upregulation of other inflammatory genes (IL-6, TNF-α, CCL2, CCL3, CCL4) in the hippocampus in mice.
| M.Wt | 400.32 | |
| Formula | C17H19Cl2N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-(5,6-dichlorobenzo[d]thiazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide |
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1. Madison N. Sluter, et al. ACS Pharmacol Transl Sci. 2023 Mar 21;6(4):587-599.
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