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Chemical Structure : UT-215
CAS No.: 2698320-28-2
Catalog No.: PC-49597ANot For Human Use, Lab Use Only.
UT-215 (UT215) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR.
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|---|---|---|---|
| 2 mg | $298 | In stock | |
| 5 mg | $498 | In stock | |
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UT-215 (UT215) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR.
UT-215 interferes liquid–liquid phase separation (LLPS), causes chromatin condensation and dissociation of AR-V7 interactome.
UT-215 possesses drug-like pharmacokinetics and metabolism properties and inhibits PCa cell proliferation and tumor growth.
| M.Wt | 338.27 | |
| Formula | C15H10F4N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-cyano-3-(trifluoromethyl)phenyl)-2-((4-fluoro-1H-pyrazol-1-yl)methyl)acrylamide |
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1. Thiyagarajan T, et al. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2211832120.
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