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Chemical Structure : Urabrelimab
CAS No.:
Catalog No.: PC-Ab1061Not For Human Use, Lab Use Only.
SRF-231 is fully human mAb for CD47, binds with high affinity to CD47, stimulates phagocytosis and the killing of cancer cells in vitro and has potent anti-tumor activity preclinically, both as monotherapy and in combination settings.disrupts the CD47/SIRPα interaction without causing hemagglutination or RBC phagocytosis. SRF231 exerts antitumor activity in vitro through both phagocytosis and cell death in a manner dependent on the activating Fc-gamma receptor (FcγR), CD32a. In tumor-bearing mic
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $358 | In stock | |
| 5 mg | $758 | In stock | |
| 10 mg | $1280 | In stock | |
| 100 mg | Get quote |
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Urabrelimab (SRF-231) is fully human mAb for CD47, binds with high affinity to CD47, stimulates phagocytosis and the killing of cancer cells in vitro and has potent anti-tumor activity preclinically, both as monotherapy and in combination settings.
Urabrelimab (SRF-231) disrupts the CD47/SIRPα interaction without causing hemagglutination or RBC phagocytosis.
Urabrelimab (SRF-231) exerts antitumor activity in vitro through both phagocytosis and cell death in a manner dependent on the activating Fc-gamma receptor (FcγR), CD32a.
In tumor-bearing mice, SRF231 increases tumor macrophage infiltration and induction of the macrophage cytokines, mouse chemoattractant protein 1 and macrophage inflammatory protein 1 alpha.
SRF231 is an investigational fully human IgG4 anti-CD47 antibody that is currently under evaluation in a phase 1 clinical trial.
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| Formula | Human IgG4 (S228P)-Kappa | |
| Appearance | Solid | |
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PBS, pH 7.0 Contains no stabilizers or preservatives |
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