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Chemical Structure : V-11-0711
Catalog No.: PC-60863Not For Human Use, Lab Use Only.
V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ.
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V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ; exhibits excellent selectivity against a panel of 50 kinases; impedes the catalytic activity and causes a reversible growth arrest, reduces phosphocholine (Pcho) in Hela cells with IC50 of <1 uM; also shows synergetic cytotoxic effects combined with chemotherapeutic temozolomide in some cancer cell lines.
| M.Wt | 421.581 | |
| Formula | C27H35NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Falcon SC, et al. Oncogenesis. 2013;2:e38.
2. Koch K, et al. Oncotarget. 2016 Nov 8;7(45):73414-73431.
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