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Chemical Structure : VER-155008
CAS No.: 1134156-31-2
Catalog No.: PC-42747Not For Human Use, Lab Use Only.
VER-155008 is a potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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VER-155008 is a potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78.
VER-155008 shows cellular activity in HCT116 cells (GI50= 5uM), has similar potencies in both Grp78 and Hsp70.
VER-155008 inhibits the proliferation of human breast and colon cancer cell lines with GI50s of 5.3-14.4 uM, and induces Hsp90 client protein degradation in both HCT116 and BT474 cells.
VER-155008 induced caspase-3/7 dependent apoptosis in BT474 cells.
| M.Wt | 556.4006 | |
| Formula | C25H23Cl2N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 37 mg/mL |
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| Chemical Name/SMILES |
Adenosine, 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]- |
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1. Macias AT, et al. J Med Chem. 2011 Jun 23;54(12):4034-41.
2. Massey AJ, et al. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.
3. Kim SH, et al. Biochem Biophys Res Commun. 2014 Nov 7;454(1):36-41.
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