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Chemical Structure : VER-50589
CAS No.: 747413-08-7
Catalog No.: PC-49670Not For Human Use, Lab Use Only.
VER-50589 (VER50589) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 21 nM and Kd value of 4.5 nM.
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VER-50589 (VER50589) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 21 nM and Kd value of 4.5 nM.
Cellular uptake of VER-50589 was 4-fold greater than for VER-49009.
VER-50589 caused significant reduction in cellular levels of Raf-1, and the client protein CDK4.
VER-50589 caused induction of HSP72 and HSP27 alongside depletion of client proteins, including C-RAF, B-RAF, and survivin, and the protein arginine methyltransferase PRMT5.
VER-50589 exhibited mean cellular antiproliferative GI(50) values of 78 nM against a human cancer cell line panel, induced cell cycle arrest and apoptosis.
VER-50589 induced growth inhibition in HCT116 human colon cancer xenografts
| M.Wt | 388.80 | |
| Formula | C19H17ClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide |
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1. Sharp SY, et al. Mol Cancer Ther. 2007 Apr;6(4):1198-211.
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