VHL-IN-15 | VHL/HIF-1α inhibitor | Probechem Biochemicals

Chemical Structure : VHL-IN-15

Catalog No.: PC-62451Not For Human Use, Lab Use Only.

VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction..

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Biological Activity

VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.

M.Wt	410.43
Formula	C21H22N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide

1. Buckley DL, et al. J Am Chem Soc. 2012 Mar 14;134(10):4465-8.

2. Van Molle I, et al. Chem Biol. 2012 Oct 26;19(10):1300-12.