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Chemical Structure : VIS351
Catalog No.: PC-35777Not For Human Use, Lab Use Only.
VIS351 (VIS-351) is a potent activator of the immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated function of the IDO1 enzyme with Kd of 1.9 uM.
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VIS351 (VIS-351) is a potent activator of the immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated function of the IDO1 enzyme with Kd of 1.9 uM; demonstrates moderate cellular inhibitor activity (IC50=11.463 μM), does not show any catalytic inhibition of the recombinant IDO1 enzyme; also activates the ITIM-mediated signaling of IDO1 in mouse plasmacytoid dendritic cells, conferring those cells an immunosuppressive phenotype detectable in vivo.
| M.Wt | 294.398 | |
| Formula | C19H22N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Albini E, et al. Biochem Pharmacol. 2018 Oct 31. pii: S0006-2952(18)30467-2.
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