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Chemical Structure : VK-II-86
CAS No.: 955371-84-3
Catalog No.: PC-38485Not For Human Use, Lab Use Only.
VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).
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|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $788 | In stock | |
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VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).
VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.
VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.
VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.
| M.Wt | 420.5 | |
| Formula | C25H28N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol |
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1. Zhou Q, et al. Nat Med. 2011 Jul 10;17(8):1003-9.
2. Gonano LA, et al. Circ J. 2018 Dec 25;83(1):41-51.
3. Robinson VM, et al. Br J Pharmacol. 2021 Dec 7. doi: 10.1111/bph.15775.
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