You are here:Home-Chemical Inhibitors & Agonists-PI3K/Akt/mTOR Pathway-PTEN-VO-Ohpic trihydrate
VO-Ohpic trihydrate

Chemical Structure : VO-Ohpic trihydrate

CAS No.: 476310-60-8

VO-Ohpic trihydrate (VO-Ohpic;VO Ohpic)

Catalog No.: PC-43375Not For Human Use, Lab Use Only.

VO-Ohpic trihydrate (VO-Ohpic) is a potent, selective and reversible PTEN inhibitor with IC50 of 35 nM in vitro.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $138 In stock
50 mg $218 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VO-Ohpic trihydrate (VO-Ohpic) is a potent, selective and reversible PTEN inhibitor with IC50 of 35 nM in vitro。
VO-Ohpic specifically inhibits PTEN’s cellular enzymatic activity, which in turn activates downstream targets such as Akt and FoxO3a, inhibits cell viability, cell proliferation and colony formation, and induces senescence-associated β-galactosidase activity in Hep3B cells (low PTEN expression)。
VO-Ohpic increases cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations。
VO-Ohpic decreases left ventricular systolic pressure and heart rate before ischemia in mice.

Physicochemical Properties

M.Wt 415.2032
Formula C12H16N2O11V+
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO; H2O: < 0.1 mg/mL

Chemical Name/SMILES

Vanadate(1-), aqua(3-hydroxy-2-pyridinecarboxylato-κN1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxo-, hydrogen, trihydrate, (OC-6-45)- (9CI)

References

1. Rosivatz E, et al. ACS Chem Biol. 2006 Dec 15;1(12):780-90.

2. Zu L, et al. Eur J Pharmacol. 2011 Jan 10;650(1):298-302.

3. Mak LH, et al. J Chem Biol. 2010 Oct;3(4):157-63.

4. Augello G, et al. Cell Cycle. 2016;15(4):573-83.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: