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Chemical Structure : VPC14449
CAS No.: 1621375-32-3
Catalog No.: PC-61774Not For Human Use, Lab Use Only.
VPC14449 (VPC-14449) is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM, without affecting AR protein expression.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VPC14449 (VPC-14449) is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM, without affecting AR protein expression.
VPC14449 effectively blocks transcriptional activity of full-length and splice variant AR forms at low to sub-micromolar concentrations.
VPC14449 reduces tumor volume and abolishes PSA production in LNCaP xenograft model.
| M.Wt | 394.085 | |
| Formula | C10H10Br2N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine |
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1. Dalal K, et al. Mol Cancer Ther. 2017 Aug 3. pii: molcanther.0259.2017.
2. Dalal K, et al. J Biol Chem. 2014 Sep 19;289(38):26417-29.
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