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Chemical Structure : VT-1598
CAS No.: 2089320-99-8
Catalog No.: PC-61752Not For Human Use, Lab Use Only.
VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote |
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VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM.
VT-1598 is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4.
VT-1598 exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens.
| M.Wt | 584.535 | |
| Formula | C31H20F4N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-4-((4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)ethynyl)phenoxy)methyl)benzonitrile |
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1. Hargrove TY, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00570-17.
2. Yates CM, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248.
3. Wiederhold NP, et al. J Antimicrob Chemother. 2018 Feb 1;73(2):404-408.
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