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Chemical Structure : VU0360172
CAS No.: 1310012-12-4
Catalog No.: PC-49074Not For Human Use, Lab Use Only.
VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM.
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VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM.
VU0360172 displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors.
VU0360172 exhibits antipsychotic-like activity in a rodent model, also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.
| M.Wt | 294.329 | |
| Formula | C18H15FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide |
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1. Celli R, et al. Neuropharmacology. 2020 Nov 1;178:108240.
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