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VU0410425

Chemical Structure : VU0410425

CAS No.: 1341167-72-3

VU0410425 (VU 0410425)

Catalog No.: PC-62956Not For Human Use, Lab Use Only.

VU0410425 is a potent, selective negative allosteric modulator of rat mGluR1 with IC50 of 140 nM, inactive at human mGluR1 (IC50>30 uM)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VU0410425 is a potent, selective negative allosteric modulator of rat mGluR1 with IC50 of 140 nM, inactive at human mGluR1 (IC50>30 uM).

Physicochemical Properties

M.Wt 369.805
Formula C19H16ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[3-Chloro-4-[(1S,5R)-6,6-dimethyl-2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl]phenyl]pyridine-2-carboxamide

References

1. Cho HP, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.

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