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Chemical Structure : VU0424238
Catalog No.: PC-63197Not For Human Use, Lab Use Only.
VU0424238 (Auglurant) is a potent, selective, orally active mGlu5 negative allosteric modulator with Ki of 4.4 nM, displays >900-fold selectivity for mGlu5 versus the other mGlu receptors.
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VU0424238 (Auglurant) is a potent, selective, orally active mGlu5 negative allosteric modulator with Ki of 4.4 nM, displays >900-fold selectivity for mGlu5 versus the other mGlu receptors; demonstrates 50% receptor occupancy at an oral dose of 0.8 mg/kg in rats and an intravenous dose of 0.06 mg/kg in baboons.
| M.Wt | 325.303 | |
| Formula | C16H12FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Felts AS, et al. J Med Chem. 2017 Jun 22;60(12):5072-5085.
2. Crouch RD, et al. Drug Metab Dispos. 2017 Dec;45(12):1245-1259.
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