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Chemical Structure : VU0453595
CAS No.: 1432436-13-9
Catalog No.: PC-35478Not For Human Use, Lab Use Only.
VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1).
VU0453595 reverses deficits in social interaction and cognitive function observed in rodent model of schizophrenia.
| M.Wt | 322.343 | |
| Formula | C18H15FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-[[2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one |
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1. Ghoshal A, et al. Neuropsychopharmacology. 2016 Jan;41(2):598-610.
2. Panarese JD, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3822-5.
3. Lv X, et al. Neuropharmacology. 2017 May 15;118:209-222.
4. Moran SP, et al. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771.
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