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Chemical Structure : VU 0465350
Catalog No.: PC-60769Not For Human Use, Lab Use Only.
VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.
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VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.
VU 0465350 shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK.
VU 0465350 blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
| M.Wt | 318.38 | |
| Formula | C19H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.
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