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VU 0469381

Chemical Structure : VU 0469381

CAS No.: 1062368-49-3

VU 0469381 (1LWY;VU0469381;ML347;ML 347)

Catalog No.: PC-60770Not For Human Use, Lab Use Only.

VU 0469381 (ML347) is a potent, sellective BMP receptor ALK2 antaognist with Ki of 32 nM, with no affinity for ALK3/4/5/6.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VU 0469381 (ML347) is a potent, sellective BMP receptor ALK2 antaognist with Ki of 32 nM, with no affinity for ALK3/4/5/6.

    Physicochemical Properties

    M.Wt 352.397
    Formula C22H16N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

    References

    1. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.

    2. Engers DW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

    3. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.

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