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VU534

Chemical Structure : VU534

CAS No.: 923509-20-0

VU534 (VU 534)

Catalog No.: PC-20921Not For Human Use, Lab Use Only.

VU534 is a small molecule activator of N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) with EC50 of 0.3 uM, enhances efferocytosis by macrophages.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VU534 is a small molecule activator of N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) with EC50 of 0.3 uM, enhances efferocytosis by macrophages.
VU534 (10 uM) increases the NAPE-PLD activity of RAW264.7 macrophages.
VU534 enhances efferocytosis in a NAPE-PLD-dependent manner in bone-marrow derived macrophages (BMDM).

Physicochemical Properties

M.Wt 447.54
Formula C21H22FN3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(C1CCN(S(=O)(C2=CC=C(F)C=C2)=O)CC1)NC3=NC4=CC(C)=CC(C)=C4S3

References

1. Jonah E Zarrow, et al. bioRxiv. 2023 Feb 28;2023.01.25.525554.

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