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Chemical Structure : VU6005649
CAS No.: 2137047-43-7
Catalog No.: PC-60162Not For Human Use, Lab Use Only.
VU6005649 is a potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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VU6005649 is a potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively.
VU6005649 displays no activity for mGlu4 (EC50>10 uM).
VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild type mice.
| M.Wt | 357.284 | |
| Formula | C16H12F5N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine |
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1. Abe M, et al. ACS Med Chem Lett. 2017 Sep 1;8(10):1110-1115.
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