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Chemical Structure : VU6010608
Catalog No.: PC-60149Not For Human Use, Lab Use Only.
VU6010608 is a potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM.
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VU6010608 is a potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM.
VU6010608 shows no activity against mGlu1,2,3,4,5,6,8, as well as a penel of 68 GPCRs, ion channels and transporters (IC50>10 uM).
VU6010608 blocks long-term potentiation (LTP) at SC-CA1 synapses in mice brain slices induced by high frequency stimulation.
| M.Wt | 408.337 | |
| Formula | C18H15F3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carson W. Reed, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1326-1330.
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