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Chemical Structure : VU6012962
CAS No.: 2313526-86-0
Catalog No.: PC-36001Not For Human Use, Lab Use Only.
VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.35 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.35 uM.
VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes and across large ancillary pharmacology panels.
VU6012962 decreases anxiety in the elevated zero maze (EZM) assay in mice.
| M.Wt | 448.402 | |
| Formula | C21H19F3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide |
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1. Reed CW, et al. J Med Chem. 2019 Jan 4. doi: 10.1021/acs.jmedchem.8b01810.
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