VU6016235

Chemical Structure : VU6016235

Catalog No.: PC-24342Not For Human Use, Lab Use Only.

VU6016235 is a potent, selective, orally active M4 mAChR positive allosteric modulator (PAM) with EC50 of 140 nM (hM4), has >148-fold selectivity over other subtypes mAChRs.

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Biological Activity

VU6016235 is a potent, selective, orally active M4 mAChR positive allosteric modulator (PAM) with EC50 of 140 nM (hM4), has >148-fold selectivity over other subtypes mAChRs.
VU6016235 (1-10 mg/kg), administered orally, reverses amphetamine-induced hyperlocomotion in male Sprague–Dawley rats.

Physicochemical Properties

M.Wt	378.49
Formula	C21H22N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(((2,4-dimethylpyrido[4',3':4,5]thieno[2,3-d]pyrimidin-8-yl)amino)methyl)phenyl)propan-2-ol

References

1. Engers JL, et al. ACS Chem Neurosci. 2024 Sep 24;15(20):3744-54.

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VU6016235

Biological Activity

Physicochemical Properties

References

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