VU6052254

Chemical Structure : VU6052254

Catalog No.: PC-26504Not For Human Use, Lab Use Only.

VU6052254 is a potent, selective muscarinic acetylcholine receptor subtype 1 (M1) positive allosteric modulator (PAM) with EC50 of 59 nM.

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Biological Activity

VU6052254 is a potent, selective muscarinic acetylcholine receptor subtype 1 (M1) positive allosteric modulator (PAM) with EC50 of 59 nM.

M.Wt	448.47
Formula	C25H22F2N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2,6-difluoro-4-(7-(2-hydroxypropan-2-yl)-2-methyl-2H-indazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

1. Julie L Engers, et al. ACS Chem Neurosci. 2025 Dec 17;16(24):4741-4750.